0.99版本的变化- - - - - - - - - - - - - - - - - - - - - - - o最初版本新特性。0.99版本1的变化- - - - - - - - - - - - - - - - - - - - - - - o固定一个bug newSeqCountSet在处理输入实验设计。o固定一个错误计算当地的罗斯福。o选项添加到模式色散和意思表达之间的关系。1.2.0-1版本的变化- - - - - - - - - - - - - - - - - - - - - - - o固定一个错误计算当地的罗斯福。o基因改变处理方式与所有0计数。现在这些基因的罗斯福是指定为0。1.6.0版本的变化- - - - - - - - - - - - - - - - - - - - - - - o实现方法检测不同甲基化位点(DML)。1.7.0版本的变化- - - - - - - - - - - - - - - - - - - - - - - o增加了对多因素实验设计的功能。目前磨边机功能用于glm配件和假设检验。 DSS only provide functions for dispersion estimation. CHANGES IN VERSION 2.0.0 ---------------------- o Implemented methods for detecting differentially methylated regions (DMR). o Modified the algorithm for computing variances with smoothing. o Add function to detect DML for general experimental design. o Add function to detect DML for general experimental design. CHANGES IN VERSION 2.5.0 ---------------------- Modify the parallel computing part in DML testing. We now use the 'mcapply' function in 'parallel' package to implement parallelization. Note that older version of DSS (<2.4x) used the 'bplapply' function in 'BiocParallel' package. However, that function somehow has significantly reduced performance in the new release (>1.25), so we switched to mcapply. A drawback is that the progress bar cannot be displayed under the paralelle computing setting.