版本1.14.1的更改---------------------------- o ms_keggnetwork返回交互子类型（例如激活）而不是类型（例如Pprel）。谢谢Shilpa Harshan注意到这一点！版本1.7.12的变化---------------------------------- o代谢信号将KEGG代谢和信号网络与Omnipath和Trrust中报道的调节互动集成在一起。o新功能：“ ms2_ppinetwork（）”和“ ms2_mergenetworks（）”。版本1.7.8的更改------------------------------ o代谢信号包括一个新功能：“ ms_getPathids（）”，该功能允许检索标识符（IDS）（IDS）给定生物体的所有代谢和信号KEGG途径。o“ ms_keggnetwork（）”现在可以将kegg ids转换为entrez基因ID（usevent_genes = true，convert_entrez = true）。o“ ms_filternetwork（）”已更名为“ ms_topology -filter”。版本1.7.2的更改------------------------------ o功能名称的重大更改：o“ metaboSignal_matrix（）”重命名为“ ms_keggnetwork” o“ o” metabosignal_distances（）“重命名为“ ms_distances” o“ odebosignal_networkCyToscape（）”重命名为“ ms_shortestpathsnetwork” o“ ms_tocytoscape（）”重命名为“ ms_exportCyCytoscape” o's_changeNames（）MS_CHANGENAMES（）RENAMES_CHANGENAMES（）ms_filternetwork“ o” ms_findkegg（）“更名为“ ms_keggfinder” o“ ms_getKegg_geneid”重命名为“ ms_convertgene” o“ ms_nodebw（）”将其重命名为“ ms_nodebw” ms_nodebw“ o” ms_replacenode（ms_replacenode（） renamed as "MS_removeNode" o "MS_FindMappedNodes()" renamed as "MS_findMappedNodes" o New functions: o "MS_tissueFilter()": allows filtering a network based on tissue expression data. o Functions removed: o "MS_interactionType()": interactions can be now retrieved directly from MS_keggNetwork. o Functionality changes: o "MS_keggNetwork()": output networks are now formatted as 3-column matrices, where the third column indicates interaction type. Unlike, MetaboSignal_matrix, “MS_keggNetwork()" does not perform network filtering by tissue expression data. Tissue filtering is now done with "MS_tissueFilter()". Also, the compound nodes of the networks are not only metabolites, but also drugs and glycans. o "MS_distances()", "MS_shortestPathNetworks()": use network nodes (i.e. KEGG IDs) as source nodes, not entrez IDs or gene symbols. However, the function "MS_convertGene()" allows to easily convert entrez IDs or gene symbols into KEGG IDs. CHANGES IN VERSION 1.7.1 ----------------------- o Significant improvements in the tissue-filtering option from "MetaboSignal_matrix()". o Cytoscape .txt files are now exported with a header. CHANGES IN VERSION 1.1.6 ----------------------- o MetaboSignal includes a new function: "MS_interactionType()". This function allows getting the interaction subtype between signaling nodes. The output matrix generated by this function can be used for "MetaboSignal_NetworkCytoscape()" and also for "MS_GetShortestpaths()". o "MS_GetShortestpaths()" has been modified and now the output shortest path(s) can be represented as a network-table (i.e. 2-column matrix).