1.8.0版本的变化o引入了新功能MDtest。它实现了基于MST中样本排序的非参数多元均值检验，类似于函数KStest，但检验统计量是两个条件的cdf之间的平均偏差。o引入了新函数RMDtest。它实现了基于MST中样本排序的非参数多元方差检验，类似于函数RKStest，但检验统计量是两个条件的cdf之间的平均偏差。o引入了AggrFtest新函数。它通过使用Fisher概率组合方法聚合f检验获得的单变量p值来实现非参数方差检验。它检验了一个基因集中的所有基因在两种条件下的方差均无显著差异的假设与另一种假设，即该基因集中至少有一个基因在两种条件下的方差均有显著差异。o新函数findMST2。介绍了PPI。它查找与函数findMST2类似的第一个和第二个mst的并集，但它接受类igraph对象作为输入，而不是基因表达数据的矩阵。输入图对象表示一个蛋白质-蛋白质相互作用(PPI)网络，可以是二进制的或加权的，有向的或无向的。 o New wrapper function TestGeneSets is introduced. It performs a specific statistical method from the ones available in package GSAR for multiple gene sets. The gene sets are provided as a list of character vectors where each entry has the feature (gene) identifiers in a single gene set. o New argument pvalue.only added to all available statistical methods in the package. When pvalue.only=TRUE (default), each statistical method returns the p-value only. When pvalue.only=FALSE, each statistical method returns a list of length 3 consisting of the observed statistic, vector of permuted statistics, and p-value. o New arguments leg.x, leg.y, group1.name, group2.name, label.color, label.dist, vertex.size, vertex.label.font, and edge.width added to function plotMST2.pathway to allow more flexibility in generating plots. The values of most of these arguments are passed to function plot.igraph. Changes in version 1.4.0 o New argument return.weights added to function plotMST2.pathway. If return.weights=TRUE, the weight vectors found by GSNCA for the genes under two classes are returned as a 2-column matrix. Changes in version 1.2.2 o Bug fix in function HDP.ranking to accomodate the changes in package igraph (version 1.0.1). o Additional steps added to the code of the second case study in the vignette to filter C2 gene sets properly. o Minor changes in the vignette. Changes in version 1.0.0 o The package provides two-sample nonparametric multivariate statistical methods to test specific alternative hypotheses against a null hypothesis. o GSAR depends on package igraph to handle graphs in objects of class igraph and uses some functions too. o New capabilities and future changes will be reported in subsequent versions.