1.4版的更改。x ------------------------ BUG修复o固定未初始化变量导致轻微随机行为。o修正错误阻塞替代PQS与零长度循环被发现。o固定低效循环通过长非鸟嘌呤序列区域。o更新默认评分参数，使组合表现稍好。移除了边缘不匹配的容易出错的特殊支持。o在计算循环长度均值时，固定整数除法为浮点除法。1.3版的更改。x ------------------------新功能:o添加估计完成时间(ETTC)到进度线。o通过对G4-seq实验数据的训练和对一组已知文献中的四重复合物进行联合测试，获得了新的评分参数默认值。 o New PQS metadata reported: number of tetrads, bulges, mismatches and loop lengths. To get this data, use elementMetadata accessor function. o New algorithm option: reporting of all overlapping PQS. o Score distribution is reported. For each sequence position you get maximal score of PQS that was found overlapping the position. For details, see scoreDistribution function. o Novel scoring parameter: exponent of loop length mean in the scoring equation to express non-linear dependency of the PQS propensity to the loop lengths. BUG FIXES o Minimal loop length is set back to 0 by default, but only one zero-length loop is allowed by the scoring system. o Fixed unintentional cast of loop length mean factor and loop standard deviation factors from float to integer. CHANGES IN VERSION 1.2.x ------------------------ BUG FIXES o Minimal loop length is now set to 1 by default. o Removed linking dependency on the flowCore package. o Fixed bug responsible for a segmentation fault. Great credit belongs to Diego Andino for sending a bug report. CHANGES IN VERSION 1.0.0 ------------------------ o Novel algorithm for identification of potential intramolecular G-quadruplex (G4) patterns in DNA sequence. o Supports multiple defects in G-runs like bulges or mismatches. o Provides the most accurate results currently available. o Highly customizable to detect even novel G4 types that might be discovered in the future.