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319.05 l 294.08 319.05 l 294.10 319.05 l 294.13 319.05 l 294.41 319.24 l 294.85 319.73 l 295.68 320.94 l 296.37 321.18 l 296.87 321.18 l 296.92 321.18 l 296.98 321.18 l 297.06 321.18 l 297.23 321.18 l 297.28 321.18 l 297.45 321.18 l 297.70 321.18 l 297.81 321.18 l 297.95 321.18 l 297.95 321.18 l 298.97 322.26 l 299.05 322.26 l 299.27 322.31 l 300.10 322.92 l 300.10 322.92 l 300.27 322.92 l 300.40 322.92 l 301.15 323.82 l 302.26 325.28 l 303.00 326.15 l 303.31 326.31 l 303.61 326.46 l 306.65 330.90 l 307.51 331.71 l 307.51 331.71 l 308.03 332.00 l 309.22 332.57 l 309.38 332.57 l 309.38 332.57 l 309.52 332.57 l 309.55 332.57 l 309.88 332.72 l 311.13 334.21 l 311.60 334.56 l 312.78 335.75 l 312.89 335.75 l 313.83 336.54 l 314.05 336.54 l 314.19 336.54 l 314.47 336.54 l 314.66 336.54 l 315.10 336.81 l 315.68 337.28 l 316.84 338.55 l 317.43 338.91 l 317.87 338.91 l 318.09 338.91 l 318.17 338.91 l 318.56 338.91 l 318.97 338.91 l 319.58 338.91 l 319.86 338.91 l 319.86 338.91 l 319.86 338.91 l 319.91 338.91 l 320.93 339.60 l 320.93 339.60 l 321.27 339.60 l 321.60 339.60 l 321.60 339.60 l 323.09 341.01 l 323.64 341.37 l 324.33 341.91 l 325.16 341.97 l 325.74 341.97 l 325.99 341.97 l 326.13 341.97 l 326.38 341.97 l 326.38 341.97 l 326.38 341.97 l 326.52 341.97 l 326.96 342.13 l 327.18 342.13 l 328.59 343.49 l 329.03 343.53 l 329.03 343.53 l 329.58 343.57 l 329.75 343.57 l 330.88 344.48 l 331.24 344.48 l 331.35 344.48 l 332.07 344.99 l 332.95 345.68 l 333.67 346.18 l 334.28 346.25 l 334.50 346.25 l 334.58 346.25 l 334.89 346.27 l 335.72 346.88 l 336.05 346.92 l 336.33 346.92 l 337.21 347.58 l 337.73 347.84 l 338.78 348.67 l 339.34 348.95 l 339.72 349.05 l 340.08 349.12 l 340.47 349.22 l 341.13 349.50 l 341.33 349.50 l 342.21 350.13 l 343.09 350.75 l 343.43 350.78 l 344.45 351.53 l 345.14 351.94 l 346.24 352.62 l 346.58 352.62 l 346.88 352.62 l 347.18 352.62 l 347.18 352.62 l 347.93 352.62 l 347.96 352.62 l 350.28 354.66 l 350.64 354.69 l 350.94 354.69 l 352.32 355.48 l 352.32 355.48 l 352.85 355.48 l 353.40 355.48 l 353.57 355.48 l 353.65 355.48 l 354.56 356.05 l 355.25 356.41 l 356.36 357.17 l 356.94 357.41 l 358.18 357.82 l 358.18 357.82 l 358.35 357.82 l 359.56 358.66 l 360.28 359.03 l 360.64 359.05 l 361.14 359.21 l 363.65 360.82 l 363.68 360.82 l 363.87 360.82 l 364.48 361.07 l 365.17 361.39 l 367.33 363.05 l 369.65 364.56 l 369.65 364.56 l 370.04 364.56 l 371.39 365.39 l 371.67 365.39 l 372.05 365.42 l 372.99 365.94 l 373.63 366.16 l 374.29 366.16 l 374.32 366.16 l 375.26 366.67 l 375.70 366.74 l 376.25 366.75 l 376.45 366.75 l 377.99 367.79 l 379.24 368.55 l 379.98 368.87 l 382.28 370.53 l 383.57 371.32 l 385.04 371.97 l 385.04 371.97 l 385.48 371.97 l 387.53 373.38 l 388.52 373.86 l 388.88 373.86 l 390.87 375.21 l 391.67 375.55 l 392.33 375.76 l 392.72 375.76 l 393.19 375.81 l 396.51 378.02 l 396.73 378.02 l 397.11 378.02 l 397.67 378.02 l 397.92 378.02 l 398.30 378.02 l 399.68 378.75 l 400.02 378.75 l 400.48 378.80 l 401.45 379.07 l 401.65 379.07 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 270.23 276.96 m 401.62 276.96 l S 270.23 276.96 m 270.23 270.98 l S 314.03 276.96 m 314.03 270.98 l S 357.82 276.96 m 357.82 270.98 l S 401.62 276.96 m 401.62 270.98 l S BT 0.000 0.000 0.000 rg /F1 1 Tf 10.00 0.00 0.00 10.00 257.72 255.44 Tm (0.000) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 301.52 255.44 Tm (0.005) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 345.31 255.44 Tm (0.010) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 389.11 255.44 Tm (0.015) Tj ET 265.00 294.96 m 265.00 379.48 l S 265.00 294.96 m 259.03 294.96 l S 265.00 316.09 m 259.03 316.09 l S 265.00 337.22 m 259.03 337.22 l S 265.00 358.35 m 259.03 358.35 l S 265.00 379.48 m 259.03 379.48 l S BT /F1 1 Tf 0.00 10.00 -10.00 0.00 250.66 285.23 Tm (0.02) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 250.66 327.49 Tm (0.06) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 250.66 369.75 Tm (0.10) Tj ET 265.00 276.96 m 406.90 276.96 l 406.90 383.00 l 265.00 383.00 l 265.00 276.96 l S Q q 216.00 216.00 216.00 216.00 re W n BT 0.000 0.000 0.000 rg /F1 1 Tf 10.00 0.00 0.00 10.00 318.30 231.54 Tm (p-value) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 226.76 312.33 Tm (q-value) Tj ET Q q 49.00 60.96 141.90 106.04 re W n Q q 49.00 60.96 141.90 106.04 re W n 0.000 0.000 0.000 RG 0.75 w [] 0 d 54.26 64.88 m 63.13 65.19 l 63.13 65.50 l 63.13 65.81 l 63.13 66.12 l 63.13 66.43 l 63.13 66.74 l 63.13 67.04 l 63.13 67.35 l 63.13 67.66 l 63.13 67.97 l 63.13 68.28 l 63.13 68.59 l 63.13 68.90 l 63.13 69.21 l 63.13 69.51 l 63.13 69.82 l 65.28 70.13 l 65.69 70.44 l 67.96 70.75 l 70.45 71.06 l 71.97 71.37 l 71.97 71.68 l 71.97 71.98 l 75.42 72.29 l 75.76 72.60 l 75.76 72.91 l 75.76 73.22 l 75.76 73.53 l 75.76 73.84 l 75.76 74.15 l 75.76 74.45 l 75.76 74.76 l 75.76 75.07 l 75.76 75.38 l 75.76 75.69 l 75.76 76.00 l 75.76 76.31 l 75.76 76.62 l 75.76 76.92 l 75.76 77.23 l 75.76 77.54 l 75.76 77.85 l 75.76 78.16 l 75.76 78.47 l 75.76 78.78 l 75.76 79.09 l 77.09 79.39 l 77.20 79.70 l 77.91 80.01 l 77.91 80.32 l 77.91 80.63 l 77.91 80.94 l 77.91 81.25 l 77.91 81.56 l 77.91 81.86 l 77.91 82.17 l 77.91 82.48 l 77.91 82.79 l 77.91 83.10 l 77.91 83.41 l 77.91 83.72 l 77.91 84.03 l 77.91 84.33 l 77.91 84.64 l 77.91 84.95 l 77.91 85.26 l 77.91 85.57 l 77.91 85.88 l 77.91 86.19 l 77.91 86.50 l 78.01 86.80 l 78.20 87.11 l 81.19 87.42 l 82.09 87.73 l 83.22 88.04 l 86.61 88.35 l 86.61 88.66 l 86.61 88.97 l 86.61 89.27 l 87.26 89.58 l 87.32 89.89 l 88.40 90.20 l 88.75 90.51 l 88.75 90.82 l 89.55 91.13 l 89.55 91.44 l 89.79 91.75 l 90.36 92.05 l 90.36 92.36 l 90.59 92.67 l 90.62 92.98 l 90.62 93.29 l 91.64 93.60 l 94.23 93.91 l 95.49 94.22 l 96.21 94.52 l 96.21 94.83 l 96.21 95.14 l 96.21 95.45 l 96.21 95.76 l 96.21 96.07 l 96.63 96.38 l 97.16 96.69 l 97.16 96.99 l 97.16 97.30 l 97.16 97.61 l 97.64 97.92 l 97.87 98.23 l 97.87 98.54 l 98.39 98.85 l 98.39 99.16 l 98.39 99.46 l 98.39 99.77 l 98.39 100.08 l 98.39 100.39 l 98.42 100.70 l 98.42 101.01 l 98.42 101.32 l 98.42 101.63 l 99.63 101.93 l 99.63 102.24 l 99.88 102.55 l 100.35 102.86 l 100.66 103.17 l 100.74 103.48 l 100.82 103.79 l 100.90 104.10 l 100.90 104.40 l 105.27 104.71 l 105.34 105.02 l 105.34 105.33 l 105.34 105.64 l 105.34 105.95 l 105.34 106.26 l 105.59 106.57 l 106.25 106.87 l 107.86 107.18 l 108.19 107.49 l 108.19 107.80 l 108.19 108.11 l 108.19 108.42 l 108.19 108.73 l 108.19 109.04 l 108.19 109.34 l 108.19 109.65 l 108.19 109.96 l 108.19 110.27 l 108.19 110.58 l 108.19 110.89 l 109.63 111.20 l 109.63 111.51 l 109.70 111.81 l 110.51 112.12 l 110.51 112.43 l 110.51 112.74 l 110.51 113.05 l 111.71 113.36 l 113.67 113.67 l 114.83 113.98 l 115.04 114.28 l 115.25 114.59 l 121.19 114.90 l 122.28 115.21 l 122.28 115.52 l 122.66 115.83 l 123.42 116.14 l 123.42 116.45 l 123.42 116.75 l 123.42 117.06 l 123.42 117.37 l 123.62 117.68 l 125.62 117.99 l 126.08 118.30 l 127.68 118.61 l 127.68 118.92 l 128.73 119.22 l 128.73 119.53 l 128.73 119.84 l 128.73 120.15 l 128.73 120.46 l 129.10 120.77 l 129.72 121.08 l 131.42 121.39 l 131.91 121.70 l 131.91 122.00 l 131.91 122.31 l 131.91 122.62 l 131.91 122.93 l 131.91 123.24 l 131.91 123.55 l 131.91 123.86 l 131.91 124.17 l 131.91 124.47 l 131.91 124.78 l 132.83 125.09 l 132.83 125.40 l 132.83 125.71 l 132.83 126.02 l 132.83 126.33 l 134.72 126.64 l 135.21 126.94 l 135.92 127.25 l 136.01 127.56 l 136.01 127.87 l 136.01 128.18 l 136.01 128.49 l 136.01 128.80 l 136.01 129.11 l 136.01 129.41 l 136.01 129.72 l 136.21 130.03 l 136.21 130.34 l 138.04 130.65 l 138.09 130.96 l 138.09 131.27 l 138.15 131.58 l 138.15 131.88 l 139.36 132.19 l 139.36 132.50 l 139.36 132.81 l 140.04 133.12 l 140.97 133.43 l 141.64 133.74 l 141.73 134.05 l 141.73 134.35 l 141.73 134.66 l 141.76 134.97 l 142.57 135.28 l 142.63 135.59 l 142.63 135.90 l 143.51 136.21 l 143.85 136.52 l 144.97 136.82 l 145.34 137.13 l 145.48 137.44 l 145.57 137.75 l 145.70 138.06 l 146.08 138.37 l 146.08 138.68 l 146.92 138.99 l 147.74 139.29 l 147.79 139.60 l 148.80 139.91 l 149.34 140.22 l 150.25 140.53 l 150.25 140.84 l 150.25 141.15 l 150.25 141.46 l 150.25 141.76 l 150.26 142.07 l 150.26 142.38 l 152.98 142.69 l 153.02 143.00 l 153.02 143.31 l 154.08 143.62 l 154.08 143.93 l 154.08 144.23 l 154.08 144.54 l 154.08 144.85 l 154.08 145.16 l 154.85 145.47 l 155.33 145.78 l 156.34 146.09 l 156.67 146.40 l 157.21 146.70 l 157.21 147.01 l 157.21 147.32 l 158.34 147.63 l 158.83 147.94 l 158.86 148.25 l 159.07 148.56 l 161.22 148.87 l 161.22 149.17 l 161.22 149.48 l 161.55 149.79 l 161.99 150.10 l 164.21 150.41 l 166.23 150.72 l 166.23 151.03 l 166.23 151.34 l 167.34 151.65 l 167.34 151.95 l 167.38 152.26 l 168.08 152.57 l 168.37 152.88 l 168.37 153.19 l 168.37 153.50 l 169.05 153.81 l 169.14 154.12 l 169.16 154.42 l 169.16 154.73 l 170.55 155.04 l 171.56 155.35 l 172.00 155.66 l 174.22 155.97 l 175.28 156.28 l 176.14 156.59 l 176.14 156.89 l 176.14 157.20 l 178.03 157.51 l 178.68 157.82 l 178.68 158.13 l 180.48 158.44 l 180.93 158.75 l 181.21 159.06 l 181.21 159.36 l 181.29 159.67 l 184.25 159.98 l 184.25 160.29 l 184.25 160.60 l 184.25 160.91 l 184.25 161.22 l 184.25 161.53 l 185.22 161.83 l 185.22 162.14 l 185.28 162.45 l 185.65 162.76 l 185.65 163.07 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 73.09 60.96 m 186.20 60.96 l S 73.09 60.96 m 73.09 54.98 l S 101.37 60.96 m 101.37 54.98 l S 129.64 60.96 m 129.64 54.98 l S 157.92 60.96 m 157.92 54.98 l S 186.20 60.96 m 186.20 54.98 l S BT 0.000 0.000 0.000 rg /F1 1 Tf 10.00 0.00 0.00 10.00 63.36 39.44 Tm (0.02) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 91.64 39.44 Tm (0.04) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 119.91 39.44 Tm (0.06) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 148.19 39.44 Tm (0.08) Tj /F1 1 Tf 10.00 0.00 0.00 10.00 176.47 39.44 Tm (0.10) Tj ET 49.00 64.57 m 49.00 157.20 l S 49.00 64.57 m 43.03 64.57 l S 49.00 80.01 m 43.03 80.01 l S 49.00 95.45 m 43.03 95.45 l S 49.00 110.89 m 43.03 110.89 l S 49.00 126.33 m 43.03 126.33 l S 49.00 141.76 m 43.03 141.76 l S 49.00 157.20 m 43.03 157.20 l S BT /F1 1 Tf 0.00 10.00 -10.00 0.00 34.66 61.79 Tm (0) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 34.66 87.11 Tm (100) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 34.66 117.99 Tm (200) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 34.66 148.86 Tm (300) Tj ET 49.00 60.96 m 190.90 60.96 l 190.90 167.00 l 49.00 167.00 l 49.00 60.96 l S Q q 0.00 0.00 216.00 216.00 re W n BT 0.000 0.000 0.000 rg /F1 1 Tf 10.00 0.00 0.00 10.00 85.76 15.54 Tm (q-value cut-off) Tj /F1 1 Tf 0.00 10.00 -10.00 0.00 10.76 79.80 Tm (significant tests) Tj ET Q q 265.00 60.96 141.90 106.04 re W n Q q 265.00 60.96 141.90 106.04 re W n 0.000 0.000 0.000 RG 0.75 w [] 0 d 270.26 64.88 m 270.67 64.94 l 271.08 64.98 l 271.50 65.02 l 271.91 65.06 l 272.32 65.10 l 272.74 65.14 l 273.15 65.18 l 273.56 65.22 l 273.98 65.26 l 274.39 65.30 l 274.80 65.34 l 275.22 65.38 l 275.63 65.42 l 276.04 65.46 l 276.46 65.50 l 276.87 65.54 l 277.28 65.67 l 277.70 65.73 l 278.11 65.87 l 278.52 66.04 l 278.94 66.17 l 279.35 66.23 l 279.76 66.29 l 280.17 66.53 l 280.59 66.62 l 281.00 66.69 l 281.41 66.76 l 281.83 66.82 l 282.24 66.89 l 282.65 66.96 l 283.07 67.03 l 283.48 67.09 l 283.89 67.16 l 284.31 67.23 l 284.72 67.30 l 285.13 67.37 l 285.55 67.43 l 285.96 67.50 l 286.37 67.57 l 286.79 67.64 l 287.20 67.70 l 287.61 67.77 l 288.02 67.84 l 288.44 67.91 l 288.85 67.97 l 289.26 68.04 l 289.68 68.25 l 290.09 68.33 l 290.50 68.48 l 290.92 68.55 l 291.33 68.62 l 291.74 68.70 l 292.16 68.77 l 292.57 68.84 l 292.98 68.91 l 293.40 68.99 l 293.81 69.06 l 294.22 69.13 l 294.64 69.20 l 295.05 69.28 l 295.46 69.35 l 295.87 69.42 l 296.29 69.49 l 296.70 69.56 l 297.11 69.64 l 297.53 69.71 l 297.94 69.78 l 298.35 69.85 l 298.77 69.93 l 299.18 70.00 l 299.59 70.09 l 300.01 70.19 l 300.42 70.75 l 300.83 70.97 l 301.25 71.24 l 301.66 71.90 l 302.07 71.99 l 302.49 72.08 l 302.90 72.17 l 303.31 72.38 l 303.73 72.48 l 304.14 72.77 l 304.55 72.93 l 304.96 73.03 l 305.38 73.27 l 305.79 73.37 l 306.20 73.51 l 306.62 73.72 l 307.03 73.82 l 307.44 73.97 l 307.86 74.07 l 308.27 74.17 l 308.68 74.48 l 309.10 75.12 l 309.51 75.50 l 309.92 75.76 l 310.34 75.87 l 310.75 75.99 l 311.16 76.10 l 311.58 76.21 l 311.99 76.32 l 312.40 76.53 l 312.81 76.76 l 313.23 76.88 l 313.64 76.99 l 314.05 77.11 l 314.47 77.33 l 314.88 77.50 l 315.29 77.62 l 315.71 77.86 l 316.12 77.98 l 316.53 78.10 l 316.95 78.21 l 317.36 78.33 l 317.77 78.45 l 318.19 78.57 l 318.60 78.69 l 319.01 78.81 l 319.43 78.92 l 319.84 79.36 l 320.25 79.48 l 320.66 79.67 l 321.08 79.92 l 321.49 80.12 l 321.90 80.27 l 322.32 80.41 l 322.73 80.56 l 323.14 80.68 l 323.56 82.04 l 323.97 82.19 l 324.38 82.33 l 324.80 82.46 l 325.21 82.59 l 325.62 82.72 l 326.04 82.93 l 326.45 83.26 l 326.86 83.88 l 327.28 84.12 l 327.69 84.26 l 328.10 84.40 l 328.52 84.53 l 328.93 84.67 l 329.34 84.81 l 329.75 84.95 l 330.17 85.09 l 330.58 85.23 l 330.99 85.37 l 331.41 85.50 l 331.82 85.64 l 332.23 86.26 l 332.65 86.40 l 333.06 86.56 l 333.47 86.98 l 333.89 87.12 l 334.30 87.27 l 334.71 87.41 l 335.13 87.97 l 335.54 88.79 l 335.95 89.35 l 336.37 89.58 l 336.78 89.81 l 337.19 92.08 l 337.60 92.63 l 338.02 92.80 l 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