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87.52 l 384.89 87.49 l 385.78 87.45 l 386.67 87.41 l 387.56 87.37 l 388.44 87.31 l 389.33 87.26 l 390.22 87.20 l 391.11 87.13 l 392.00 87.06 l 392.88 86.99 l 393.77 86.92 l 394.66 86.84 l 395.55 86.76 l 396.44 86.68 l 397.32 86.59 l 398.21 86.51 l 399.10 86.43 l 399.99 86.34 l 400.87 86.26 l 401.76 86.18 l 402.65 86.09 l 403.54 86.01 l 404.43 85.94 l 405.31 85.86 l 406.20 85.78 l 407.09 85.71 l 407.98 85.64 l 408.87 85.57 l 409.75 85.50 l 410.64 85.44 l 411.53 85.38 l 412.42 85.32 l 413.30 85.27 l 414.19 85.21 l 415.08 85.17 l 415.97 85.12 l 416.86 85.08 l 417.74 85.03 l 418.63 85.00 l 419.52 84.96 l 420.41 84.93 l 421.30 84.89 l 422.18 84.86 l 423.07 84.84 l 423.96 84.81 l 424.85 84.79 l 425.73 84.76 l 426.62 84.74 l 427.51 84.72 l 428.40 84.70 l 429.29 84.69 l 430.17 84.67 l 431.06 84.65 l 431.95 84.64 l 432.00 84.64 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 98.18 73.44 m 362.62 73.44 l S 98.18 73.44 m 98.18 66.24 l S 151.07 73.44 m 151.07 66.24 l S 203.96 73.44 m 203.96 66.24 l S 256.84 73.44 m 256.84 66.24 l S 309.73 73.44 m 309.73 66.24 l S 362.62 73.44 m 362.62 66.24 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 12.00 0.00 -0.00 12.00 94.84 47.52 Tm (2) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 147.73 47.52 Tm (4) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 200.62 47.52 Tm (6) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 253.51 47.52 Tm (8) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 303.06 47.52 Tm (10) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 355.95 47.52 Tm (12) Tj ET 59.04 84.53 m 59.04 361.87 l S 59.04 84.53 m 51.84 84.53 l S 59.04 153.87 m 51.84 153.87 l S 59.04 223.20 m 51.84 223.20 l S 59.04 292.53 m 51.84 292.53 l S 59.04 361.87 m 51.84 361.87 l S BT /F2 1 Tf 0.00 12.00 -12.00 0.00 41.76 76.19 Tm (0.0) Tj ET BT /F2 1 Tf 0.00 12.00 -12.00 0.00 41.76 145.53 Tm (0.2) Tj ET BT /F2 1 Tf 0.00 12.00 -12.00 0.00 41.76 214.86 Tm (0.4) Tj ET BT /F2 1 Tf 0.00 12.00 -12.00 0.00 41.76 284.19 Tm (0.6) Tj ET BT /F2 1 Tf 0.00 12.00 -12.00 0.00 41.76 353.53 Tm (0.8) Tj ET 59.04 73.44 m 401.76 73.44 l 401.76 372.96 l 59.04 372.96 l 59.04 73.44 l S Q q BT 0.000 0.000 0.000 rg /F3 1 Tf 14.00 0.00 -0.00 14.00 27.78 397.45 Tm (Expression density: NSMPs vs. all, and NSMP survivor curve) Tj ET BT /F2 1 Tf 12.00 0.00 -0.00 12.00 190.72 18.72 Tm (Log2\(Intensity\)) Tj ET BT /F2 1 Tf 0.00 12.00 -12.00 0.00 12.96 174.52 Tm (Probability density) Tj ET Q q 59.04 73.44 342.72 299.52 re W n 0.745 0.745 0.745 RG 0.08 w [] 0 d 1 J 1 j 10.00 M 59.04 84.53 m 401.76 84.53 l S 1.000 0.000 1.000 RG 0.75 w [] 0 d 68.92 84.60 m 69.15 84.61 l 69.38 84.62 l 69.62 84.64 l 69.85 84.66 l 70.08 84.68 l 70.31 84.71 l 70.54 84.74 l 70.77 84.78 l 71.01 84.82 l 71.24 84.87 l 71.47 84.93 l 71.70 84.99 l 71.93 85.06 l 72.16 85.15 l 72.40 85.24 l 72.63 85.34 l 72.86 85.45 l 73.09 85.58 l 73.32 85.73 l 73.55 85.88 l 73.79 86.06 l 74.02 86.25 l 74.25 86.46 l 74.48 86.69 l 74.71 86.94 l 74.94 87.21 l 75.18 87.50 l 75.41 87.82 l 75.64 88.16 l 75.87 88.52 l 76.10 88.91 l 76.33 89.32 l 76.57 89.77 l 76.80 90.24 l 77.03 90.73 l 77.26 91.25 l 77.49 91.81 l 77.73 92.39 l 77.96 93.00 l 78.19 93.64 l 78.42 94.30 l 78.65 95.01 l 78.88 95.74 l 79.12 96.50 l 79.35 97.29 l 79.58 98.11 l 79.81 98.97 l 80.04 99.87 l 80.27 100.80 l 80.51 101.76 l 80.74 102.77 l 80.97 103.83 l 81.20 104.93 l 81.43 106.07 l 81.66 107.25 l 81.90 108.50 l 82.13 109.80 l 82.36 111.15 l 82.59 112.56 l 82.82 114.02 l 83.05 115.57 l 83.29 117.17 l 83.52 118.84 l 83.75 120.57 l 83.98 122.37 l 84.21 124.25 l 84.44 126.19 l 84.68 128.21 l 84.91 130.28 l 85.14 132.43 l 85.37 134.65 l 85.60 136.92 l 85.84 139.26 l 86.07 141.65 l 86.30 144.09 l 86.53 146.59 l 86.76 149.13 l 86.99 151.71 l 87.23 154.33 l 87.46 156.98 l 87.69 159.66 l 87.92 162.36 l 88.15 165.08 l 88.38 167.82 l 88.62 170.57 l 88.85 173.34 l 89.08 176.11 l 89.31 178.89 l 89.54 181.68 l 89.77 184.48 l 90.01 187.29 l 90.24 190.10 l 90.47 192.93 l 90.70 195.77 l 90.93 198.62 l 91.16 201.49 l 91.40 204.38 l 91.63 207.29 l 91.86 210.23 l 92.09 213.19 l 92.32 216.18 l 92.55 219.20 l 92.79 222.24 l 93.02 225.33 l 93.25 228.44 l 93.48 231.58 l 93.71 234.74 l 93.95 237.92 l 94.18 241.13 l 94.41 244.35 l 94.64 247.58 l 94.87 250.82 l 95.10 254.05 l 95.34 257.27 l 95.57 260.48 l 95.80 263.67 l 96.03 266.84 l 96.26 269.96 l 96.49 273.04 l 96.73 276.08 l 96.96 279.06 l 97.19 281.99 l 97.42 284.84 l 97.65 287.63 l 97.88 290.35 l 98.12 293.01 l 98.35 295.58 l 98.58 298.07 l 98.81 300.48 l 99.04 302.83 l 99.27 305.10 l 99.51 307.28 l 99.74 309.39 l 99.97 311.43 l 100.20 313.40 l 100.43 315.30 l 100.67 317.12 l 100.90 318.88 l 101.13 320.57 l 101.36 322.20 l 101.59 323.77 l 101.82 325.26 l 102.06 326.70 l 102.29 328.07 l 102.52 329.38 l 102.75 330.62 l 102.98 331.79 l 103.21 332.90 l 103.45 333.94 l 103.68 334.91 l 103.91 335.81 l 104.14 336.63 l 104.37 337.39 l 104.60 338.07 l 104.84 338.70 l 105.07 339.24 l 105.30 339.70 l 105.53 340.11 l 105.76 340.45 l 105.99 340.73 l 106.23 340.95 l 106.46 341.10 l 106.69 341.21 l 106.92 341.27 l 107.15 341.29 l 107.38 341.26 l 107.62 341.20 l 107.85 341.11 l 108.08 340.99 l 108.31 340.84 l 108.54 340.67 l 108.78 340.48 l 109.01 340.27 l 109.24 340.04 l 109.47 339.79 l 109.70 339.52 l 109.93 339.22 l 110.17 338.90 l 110.40 338.55 l 110.63 338.16 l 110.86 337.72 l 111.09 337.24 l 111.32 336.71 l 111.56 336.11 l 111.79 335.43 l 112.02 334.67 l 112.25 333.83 l 112.48 332.89 l 112.71 331.85 l 112.95 330.68 l 113.18 329.40 l 113.41 327.99 l 113.64 326.47 l 113.87 324.80 l 114.10 322.97 l 114.34 321.02 l 114.57 318.93 l 114.80 316.70 l 115.03 314.31 l 115.26 311.78 l 115.49 309.12 l 115.73 306.34 l 115.96 303.44 l 116.19 300.39 l 116.42 297.23 l 116.65 293.98 l 116.89 290.63 l 117.12 287.20 l 117.35 283.68 l 117.58 280.10 l 117.81 276.46 l 118.04 272.79 l 118.28 269.08 l 118.51 265.34 l 118.74 261.60 l 118.97 257.86 l 119.20 254.13 l 119.43 250.42 l 119.67 246.74 l 119.90 243.11 l 120.13 239.53 l 120.36 236.00 l 120.59 232.56 l 120.82 229.19 l 121.06 225.91 l 121.29 222.71 l 121.52 219.61 l 121.75 216.63 l 121.98 213.77 l 122.21 211.01 l 122.45 208.36 l 122.68 205.84 l 122.91 203.47 l 123.14 201.22 l 123.37 199.10 l 123.60 197.09 l 123.84 195.24 l 124.07 193.52 l 124.30 191.94 l 124.53 190.47 l 124.76 189.12 l 125.00 187.92 l 125.23 186.85 l 125.46 185.88 l 125.69 185.02 l 125.92 184.26 l 126.15 183.63 l 126.39 183.09 l 126.62 182.63 l 126.85 182.24 l 127.08 181.93 l 127.31 181.69 l 127.54 181.51 l 127.78 181.36 l 128.01 181.25 l 128.24 181.17 l 128.47 181.11 l 128.70 181.05 l 128.93 181.00 l 129.17 180.93 l 129.40 180.84 l 129.63 180.72 l 129.86 180.57 l 130.09 180.38 l 130.32 180.14 l 130.56 179.82 l 130.79 179.45 l 131.02 179.02 l 131.25 178.52 l 131.48 177.94 l 131.72 177.28 l 131.95 176.54 l 132.18 175.73 l 132.41 174.85 l 132.64 173.88 l 132.87 172.83 l 133.11 171.72 l 133.34 170.53 l 133.57 169.29 l 133.80 167.97 l 134.03 166.59 l 134.26 165.17 l 134.50 163.69 l 134.73 162.18 l 134.96 160.62 l 135.19 159.02 l 135.42 157.40 l 135.65 155.76 l 135.89 154.10 l 136.12 152.42 l 136.35 150.74 l 136.58 149.05 l 136.81 147.36 l 137.04 145.68 l 137.28 144.00 l 137.51 142.34 l 137.74 140.69 l 137.97 139.06 l 138.20 137.45 l 138.43 135.87 l 138.67 134.32 l 138.90 132.79 l 139.13 131.30 l 139.36 129.84 l 139.59 128.42 l 139.83 127.04 l 140.06 125.70 l 140.29 124.39 l 140.52 123.14 l 140.75 121.92 l 140.98 120.75 l 141.22 119.62 l 141.45 118.54 l 141.68 117.51 l 141.91 116.52 l 142.14 115.57 l 142.37 114.66 l 142.61 113.80 l 142.84 112.98 l 143.07 112.20 l 143.30 111.46 l 143.53 110.75 l 143.76 110.09 l 144.00 109.46 l 144.23 108.85 l 144.46 108.28 l 144.69 107.73 l 144.92 107.22 l 145.15 106.72 l 145.39 106.25 l 145.62 105.80 l 145.85 105.37 l 146.08 104.96 l 146.31 104.57 l 146.54 104.19 l 146.78 103.82 l 147.01 103.47 l 147.24 103.14 l 147.47 102.81 l 147.70 102.50 l 147.94 102.19 l 148.17 101.90 l 148.40 101.62 l 148.63 101.35 l 148.86 101.08 l 149.09 100.83 l 149.33 100.59 l 149.56 100.35 l 149.79 100.13 l 150.02 99.91 l 150.25 99.70 l 150.48 99.49 l 150.72 99.30 l 150.95 99.10 l 151.18 98.91 l 151.41 98.73 l 151.64 98.55 l 151.87 98.37 l 152.11 98.19 l 152.34 98.02 l 152.57 97.84 l 152.80 97.65 l 153.03 97.47 l 153.26 97.28 l 153.50 97.08 l 153.73 96.88 l 153.96 96.67 l 154.19 96.45 l 154.42 96.22 l 154.66 95.99 l 154.89 95.74 l 155.12 95.48 l 155.35 95.22 l 155.58 94.94 l 155.81 94.66 l 156.05 94.36 l 156.28 94.06 l 156.51 93.75 l 156.74 93.43 l 156.97 93.10 l 157.20 92.77 l 157.44 92.44 l 157.67 92.10 l 157.90 91.76 l 158.13 91.42 l 158.36 91.08 l 158.59 90.75 l 158.83 90.41 l 159.06 90.08 l 159.29 89.76 l 159.52 89.44 l 159.75 89.13 l 159.98 88.83 l 160.22 88.53 l 160.45 88.25 l 160.68 87.98 l 160.91 87.72 l 161.14 87.47 l 161.37 87.23 l 161.61 87.01 l 161.84 86.80 l 162.07 86.60 l 162.30 86.42 l 162.53 86.24 l 162.77 86.08 l 163.00 85.94 l 163.23 85.80 l 163.46 85.67 l 163.69 85.56 l 163.92 85.46 l 164.16 85.37 l 164.39 85.29 l 164.62 85.21 l 164.85 85.15 l 165.08 85.10 l 165.31 85.05 l 165.55 85.02 l 165.78 84.99 l 166.01 84.97 l 166.24 84.96 l 166.47 84.95 l 166.70 84.96 l 166.94 84.97 l 167.17 84.98 l 167.40 85.01 l 167.63 85.04 l 167.86 85.07 l 168.09 85.12 l 168.33 85.17 l 168.56 85.22 l 168.79 85.28 l 169.02 85.35 l 169.25 85.42 l 169.48 85.50 l 169.72 85.59 l 169.95 85.68 l 170.18 85.77 l 170.41 85.87 l 170.64 85.97 l 170.88 86.07 l 171.11 86.18 l 171.34 86.29 l 171.57 86.40 l 171.80 86.51 l 172.03 86.62 l 172.27 86.73 l 172.50 86.83 l 172.73 86.94 l 172.96 87.03 l 173.19 87.13 l 173.42 87.22 l 173.66 87.30 l 173.89 87.37 l 174.12 87.44 l 174.35 87.50 l 174.58 87.54 l 174.81 87.58 l 175.05 87.61 l 175.28 87.63 l 175.51 87.63 l 175.74 87.63 l 175.97 87.62 l 176.20 87.59 l 176.44 87.55 l 176.67 87.51 l 176.90 87.46 l 177.13 87.39 l 177.36 87.32 l 177.59 87.24 l 177.83 87.15 l 178.06 87.06 l 178.29 86.96 l 178.52 86.86 l 178.75 86.76 l 178.99 86.65 l 179.22 86.54 l 179.45 86.43 l 179.68 86.32 l 179.91 86.21 l 180.14 86.10 l 180.38 85.99 l 180.61 85.89 l 180.84 85.79 l 181.07 85.69 l 181.30 85.60 l 181.53 85.51 l 181.77 85.42 l 182.00 85.34 l 182.23 85.27 l 182.46 85.19 l 182.69 85.13 l 182.92 85.07 l 183.16 85.01 l 183.39 84.96 l 183.62 84.91 l 183.85 84.87 l 184.08 84.83 l 184.31 84.79 l 184.55 84.76 l 184.78 84.73 l 185.01 84.71 l 185.24 84.68 l 185.47 84.66 l 185.71 84.64 l 185.94 84.63 l 186.17 84.61 l 186.40 84.60 l 186.63 84.59 l 186.86 84.58 l 187.10 84.58 l 187.33 84.57 l S 0.000 0.000 0.000 RG 1.50 w [] 0 d 71.73 431.20 m 74.91 431.20 l 78.08 431.20 l 81.25 430.50 l 84.43 427.47 l 87.60 424.45 l 90.77 406.68 l 93.95 395.15 l 97.12 374.00 l 100.29 346.88 l 103.47 320.79 l 106.64 285.19 l 109.81 254.23 l 112.99 229.83 l 116.16 192.79 l 119.33 166.84 l 122.51 153.84 l 125.68 142.03 l 128.85 134.43 l 132.03 118.15 l 135.20 107.10 l 138.37 98.78 l 141.55 95.29 l 144.72 92.59 l 147.89 90.43 l 151.07 88.81 l 154.24 86.75 l 157.41 85.66 l 160.59 85.47 l 163.76 85.27 l 166.93 85.07 l 170.11 84.87 l 173.28 84.67 l 176.45 84.53 l 179.63 84.53 l 182.80 84.53 l 185.97 84.53 l 189.15 84.53 l 192.32 84.53 l 195.49 84.53 l 198.67 84.53 l 201.84 84.53 l 205.01 84.53 l 208.19 84.53 l 211.36 84.53 l 214.53 84.53 l 217.71 84.53 l 220.88 84.53 l 224.05 84.53 l 227.23 84.53 l 230.40 84.53 l 233.57 84.53 l 236.75 84.53 l 239.92 84.53 l 243.09 84.53 l 246.27 84.53 l 249.44 84.53 l 252.61 84.53 l 255.79 84.53 l 258.96 84.53 l 262.13 84.53 l 265.31 84.53 l 268.48 84.53 l 271.65 84.53 l 274.83 84.53 l 278.00 84.53 l 281.17 84.53 l 284.35 84.53 l 287.52 84.53 l 290.69 84.53 l 293.87 84.53 l 297.04 84.53 l 300.21 84.53 l 303.39 84.53 l 306.56 84.53 l 309.73 84.53 l 312.91 84.53 l 316.08 84.53 l 319.25 84.53 l 322.43 84.53 l 325.60 84.53 l 328.77 84.53 l 331.95 84.53 l 335.12 84.53 l 338.29 84.53 l 341.47 84.53 l 344.64 84.53 l 347.81 84.53 l 350.99 84.53 l 354.16 84.53 l 357.33 84.53 l 360.51 84.53 l 363.68 84.53 l 366.85 84.53 l 370.03 84.53 l 373.20 84.53 l 376.37 84.53 l 379.55 84.53 l 382.72 84.53 l 385.89 84.53 l 389.07 84.53 l S 0.75 w [ 3.00 5.00] 0 d 59.04 88.00 m 401.76 88.00 l S 59.04 91.47 m 401.76 91.47 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 8.00 0.00 -0.00 8.00 100.97 89.44 Tm (0.01) Tj ET BT /F2 1 Tf 8.00 0.00 -0.00 8.00 82.46 92.91 Tm (0.02) Tj ET 153.71 73.44 m 153.71 372.96 l S 145.97 73.44 m 145.97 372.96 l S BT /F2 1 Tf 8.00 0.00 -0.00 8.00 128.96 203.95 Tm (3.81) Tj ET BT /F2 1 Tf 8.00 0.00 -0.00 8.00 141.15 186.62 Tm (4.1) Tj ET BT /F2 1 Tf 10.00 0.00 -0.00 10.00 153.17 203.47 Tm (Log\(intensity\)) Tj ET BT /F2 1 Tf 10.00 0.00 -0.00 10.00 160.91 186.14 Tm (Log\(intensity\)) Tj ET 1.000 0.000 0.000 RG 145.77 84.63 m 146.35 84.73 l 146.92 84.90 l 147.49 85.18 l 148.06 85.65 l 148.63 86.40 l 149.21 87.51 l 149.78 89.10 l 150.35 91.25 l 150.92 94.03 l 151.49 97.45 l 152.07 101.49 l 152.64 106.01 l 153.21 110.86 l 153.78 115.79 l 154.35 120.57 l 154.92 124.95 l 155.50 128.74 l 156.07 131.81 l 156.64 134.09 l 157.21 135.64 l 157.78 136.58 l 158.36 137.05 l 158.93 137.20 l 159.50 137.15 l 160.07 136.99 l 160.64 136.78 l 161.22 136.56 l 161.79 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